Deep Vein Thrombosis Research Today is a free monthly online journal that collates and summarizes the latest research about Deep Vein Thrombosis, including details on dvt, prevention, effects, causes, air travel, blood clots.

A rare incidental finding in a case of painless jaundice.

Patel SN, Baumann BM, Farmer MC

Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School-Camden, Cooper University Hospital, Camden, NJ 08103, USA.

Portal vein thrombosis secondary to protein C deficiency is a rare finding. Diagnosing a portal vein thrombosis itself is difficult due to nonspecific symptoms such as nausea, vomiting, anorexia, and weight loss. Proving that a protein C deficiency is the cause of a portal vein thrombosis is even more difficult as an extensive and thorough workup is required to rule out malignancies, myeloproliferative disorders, and hypercoaguable states which can all lead to thromboses. Patients require anticoagulation to prevent two dangerous complications of portal vein thrombosis; portal hypertension leading to esophageal varices with massive hemetemesis and extension of thrombus from the portal vein into the mesenteric veins leading to intestinal ischemia and death. In this case report, we present a patient with the complaint of painless jaundice who was found to have an incidental finding of portal vein thrombosis secondary to protein C deficiency. The different etiologies of portal vein thrombosis, along with diagnosis and treatment options will be discussed and highlighted.

Published 15 April 2008 in Am J Emerg Med, 26(4): 516.e1-2.
Full-text of this article is available online (may require subscription).

Articles on Deep Vein Thrombosis published 11 April 2008:

Surveillance bias and deep vein thrombosis in the national trauma data bank: the more we look, the more we find.   J Trauma, 64(4): 932-6; discussion 936-7.

ACKGROUND: Deep vein thrombosis (DVT) has been identified as a marker of quality of care by various governmental and consumer groups. However, the lack of standardized DVT screening systems across trauma centers may introduce surveillance bias in the rates of DVT reported. We hypothesize that trauma centers with higher rates of duplex ultrasound detect more DVTs and subsequently report higher DVT rates to the National Trauma Data Bank. METHODS: We queried the National Trauma Data Bank version ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 1 April 2008:

Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry.   Circulation, 117(13): 1711-6.

BACKGROUND: Clinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied. METHODS AND RESULTS: Using data from the international prospective Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry about patients with objectively confirmed symptomatic acute venous thromboembolism, we determined independent predictive factors for fatal PE. Between March 2001 and July 2006, 15 520 consecutive patients (mean age+/-SD, ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 31 March 2008:

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism.   Atherosclerosis, 197(2): 694-9.

Recent data have implicated a haplotype of the purinergic receptor P2Y, G-protein coupled, 12 gene (P2RY12), as potential risk determinant for atherothrombosis. However, to date, no prospective, genetic-epidemiological data are available. Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the possible association of P2RY12 genetic variants, in particular a haplotype H2 (constituted by dbSNP rs10935838, rs2046934, rs5853517, and ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 28 March 2008:

Intravitreal Avastin for macular oedema secondary to retinal vein occlusion: a prospective study.   Br J Ophthalmol, 92(4): 518-22.

OBJECTIVE: To evaluate efficacy and safety of intravitreal bevacizumab (Avastin) in eyes with macular oedema secondary to central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). METHODS: Twenty-eight consecutive patients (28 patients, 29 eyes, 8 CRVO, 21 BRVO) were enrolled in the study. Three intravitreal injections of 1 mg bevacizumab (0.04 ml) were administered at 4-week intervals; further retreatment was based on optical coherence tomography (OCT) findings. Follow-up ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 25 March 2008:

Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics.   Stroke, 39(4): 1152-8.

BACKGROUND AND PURPOSE: The risk of seizure early after the diagnosis of cerebral vein and dural sinus thrombosis (CVT) is not known, and the use of prophylactic antiepileptic (AED) medication in the acute phase of CVT is controversial. METHODS: In a multicenter, prospective, observational study, we analyzed the risk factors for seizures experienced before the diagnosis of CVT was confirmed (presenting seizures) or within the following 2 weeks (early seizures). The risk of occurrence of early ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 19 March 2008:

Gene variants associated with deep vein thrombosis.   JAMA, 299(11): 1306-14.

CONTEXT: The genetic causes of deep vein thrombosis (DVT) are not fully understood. OBJECTIVE: To identify single-nucleotide polymorphisms (SNPs) associated with DVT. DESIGN, SETTING, AND PATIENTS: We used 3 case-control studies of first DVT. A total of 19 682 gene-centric SNPs were genotyped in 443 cases and 453 controls from the Leiden Thrombophilia Study (LETS, 1988-1992). Twelve hundred six SNPs associated with DVT were reinvestigated in the Multiple Environmental and Genetic Assessment of ... [Abstract] [Full-text]

Incidence of hematoma complication with heparin venous thrombosis prophylaxis after TRAM flap breast reconstruction.   Plast Reconstr Surg, 121(4): 1101-7.

BACKGROUND: Randomized controlled studies provide ample evidence that heparin is effective in reducing the risk of thromboembolic complications. Nevertheless, plastic surgeons are often reluctant to use heparin chemoprophylaxis for fear of postoperative bleeding. The authors investigated whether heparin chemoprophylaxis was associated with postoperative hematoma that required evacuation in patients who underwent transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. ... [Abstract] [Full-text]

Articles on Deep Vein Thrombosis published 18 March 2008:

Local thrombolysis in patients with dural venous thrombosis unresponsive to heparin.   J Stroke Cerebrovasc Dis, 17(2): 95-100.

OBJECTIVE: We sought to study the efficacy and complications of local thrombolysis using urokinase in cases of cortical vein thrombosis unresponsive to conventional heparin therapy. METHODS: Patients with clinical and radiologic diagnosis of cortical vein thrombosis were taken for local thrombolysis using femoral vein approach if they did not respond to heparin therapy after 5 days of administration of the drug. Urokinase was used as the thrombolytic agent and dose was decided depending on the ... [Abstract] [Full-text]

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