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Activated protein C resistance due to factor V Leiden, elevated coagulation factor VIII and postoperative deep vein thrombosis in late breast reconstruction with a free TRAM flap: a report of two cases.

Olsson E, Höijer P

Department of Surgery, Gävle-Sandviken Central Hospital and Centre for Research and Development, Uppsala University, Gävleborg, S-801 88 Gävle, Sweden. eija.h.olsson@lg.se

Thromboembolic complications can endanger free flap surgery and cause postoperative morbidity and even mortality. The underlying cause of thrombosis is multifactorial; major surgery may trigger hereditary thrombophilic disorders leading to overt thrombotic events. This paper reports two cases with postoperative deep vein thrombosis after late breast reconstruction with a TRAM flap. Both showed APC resistance due to factor V Leiden and elevated coagulation factor VIII. One of the patients also had an event of both arterial and venous anastomotic thrombosis postoperatively.

Published 4 July 2005 in Br J Plast Surg, 58(5): 720-3.
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