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Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.

Keane PA, Ravikumar K, O'shea SI, Cleary PE

Department of Ophthalmology, Cork University Hospital, Cork, Ireland. pearsek@iol.ie

PURPOSE: To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome. DESIGN: Observational case report. METHODS: Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion. RESULTS: Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions. CONCLUSIONS: The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.

Published 2 October 2006 in Am J Ophthalmol, 142(4): 701-2.
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